The data contained within the PIN module originate entirely from peer-reviewed publications. MindSpec researchers manually curate information on direct protein interactions of ASD risk genes based on a multi-level annotation model.
The steps involved in the curation of a PIN module entry are as follows:
Consultation with publicly available molecular interaction databases (HPRD, BioGRID)
Extraction from commercial molecular interaction software (Pathway Studio 7.1)
Manual searches of PubMed using the following terms: (Gene Symbol OR Aliases) AND (interact* OR bind* OR regulat* OR function)
Verification of every interaction by manually curating information directly from primary reference articles