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PIN

About the Protein Interaction Module

The Protein Interaction (PIN) module catalogues every known interaction between gene products associated with ASD, including both protein-protein and protein-nucleic acid interactions.

Studying the many interactions that take place between proteins is crucial to understanding their functions. The PIN module of SFARI Gene serves as an up-to-date reference for all known direct interactions occurring between gene products implicated in ASD.

Published data related to an individual protein are manually reviewed and verified by our researchers. Once the evidence has been analyzed, the proteins are added into the module and organized into the genetic categories below. The PIN Module is designed to help accelerate ASD research by acting as a bioinformatics platform for network biology analysis of the molecular pathways underlying ASD pathogenesis.

Genetic Categories

1.

Rare

Rare single gene variants, disruptions/mutations, and submicroscopic deletions/duplications directly linked to ASD

2.

Syndromic

Genes implicated in syndromes in which a significant subpopulation develops symptoms of autism (examples: Angelman Syndrome, Fragile X Syndrome)

3.

Association

Small risk-conferring candidate genes with common polymorphisms identified from genetic association studies in idiopathic ASD

4.

Functional

Functional candidates not yet experimentally linked with ASD

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